Hydrogen peroxide-mediated killing of Caenorhabditis elegans: a common feature of different streptococcal species.
نویسندگان
چکیده
Recently, we reported that Streptococcus pyogenes kills Caenorhabditis elegans by the use of hydrogen peroxide (H2O2). Here we show that diverse streptococcal species cause death of C. elegans larvae in proportion to the level of H2O2 produced. H2O2 may mask the effects of other pathogenicity factors of catalase-negative bacteria in the C. elegans infection model.
منابع مشابه
Hydrogen peroxide-mediated killing of Caenorhabditis elegans by Streptococcus pyogenes.
Caenorhabditis elegans is currently introduced as a new, facile, and cheap model organism to study the pathogenesis of gram-negative bacteria such as Pseudomonas aeruginosa and Salmonella enterica serovar Typhimurium. The mechanisms of killing involve either diffusible exotoxins or infection-like processes. Recently, it was shown that also some gram-positive bacteria kill C. elegans, although t...
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ورودعنوان ژورنال:
- Infection and immunity
دوره 72 2 شماره
صفحات -
تاریخ انتشار 2004